Microarray Analysis of Thyroid Nodule Fine-Needle Aspirates Accurately Classifies Benign and Malignant Lesions
نویسندگان
چکیده
منابع مشابه
Microarray analysis of thyroid nodule fine-needle aspirates accurately classifies benign and malignant lesions.
Current preoperative diagnostic procedures for thyroid nodules rely mainly on the cytological interpretation of fine-needle aspirates (FNAs). DNA microarray analysis has been shown to reliably distinguish benign and malignant thyroid nodules in surgically resected specimens, but its diagnostic potential in thyroid FNA has not been examined. In the present study, the expression profiles of 50 be...
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The enzyme telomerase contributes to the maintenance of telomere stability (1). Although telomerase reactivation in somatic cells is not sufficient per se for the cells to proliferate indefinitely, telomerase expression and telomere stabilization appear to occur concomitantly with the attainment of immortality in cancer cells (1–3) and may contribute to tumorigenesis and neoplastic progression....
متن کاملA panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration.
PURPOSE Indeterminate thyroid lesions on fine needle aspiration (FNA) harbor malignancy in about 25% of cases. Hemi- or total thyroidectomy has, therefore, been routinely advocated for definitive diagnosis. In this study, we analyzed miRNA expression in indeterminate FNA samples and determined its prognostic effects on final pathologic diagnosis. EXPERIMENTAL DESIGN A predictive model was der...
متن کاملImaging, Diagnosis, Prognosis A Panel of Four miRNAs Accurately Differentiates Malignant from Benign Indeterminate Thyroid Lesions on Fine Needle Aspiration
Purpose: Indeterminate thyroid lesions on fine needle aspiration (FNA) harbor malignancy in about 25%of cases.Hemior total thyroidectomyhas, therefore, been routinely advocated for definitive diagnosis. In this study, we analyzed miRNA expression in indeterminate FNA samples and determined its prognostic effects on final pathologic diagnosis. Experimental Design: A predictive model was derived ...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2006
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2006.060080